Urine Metabolite Biomarkers for Sarcopenia from a 200-Participant Clinical Study

Featuring metabolomic analysis results from a cross-sectional study of 200 individuals aged 50–70 years. It identifies a panel of metabolites, including L-glutamic acid, xanthine, taurine, succinate, and L‐carnitine, associated with early sarcopenia-related metabolic changes detectable in urine. The research was conducted by Rafaela Andrade-Vieira and published under a CC BY 4.0 license.

Use Cases

• Train a classifier to predict sarcopenia-related metabolic alterations using the combined panel of L-glutamic acid, xanthine, taurine, succinate, and L‐carnitine.
• Analyze correlations between metabolite levels (e.g., taurine, succinate) and participant assessments like the Short Physical Performance Battery (SPPB) or dual-energy X-ray absorptiometry (DXA).
• Validate the predictive performance of the identified metabolite panel for early muscle health decline against International Physical Activity Questionnaire (IPAQ) scores.
• Investigate the relationship between serum and urine levels of specific metabolites like L‐carnitine for non-invasive biomarker development.

Strengths

• Data is derived from a clinical study with 200 participants, providing a substantive sample for analysis.
• Includes targeted metabolomic analysis on a specific panel of five metabolites linked to sarcopenia.
• Study design incorporates multiple assessment methods, including DXA, SPPB, and IPAQ, for a multi-faceted view.

Limitations

• The dataset is small in file size (109.2 KB), suggesting it is likely a summary or results document rather than raw tabular data.
• Cross-sectional design limits the ability to establish causal relationships or track metabolic changes over time.
• The participant age range (50–70 years) and focus on sarcopenia may limit generalizability to other populations or conditions.

Provenance

Source

figshare, authored by Rafaela Andrade-Vieira.

Collection Method

Targeted metabolomic analyses performed on serum and urine samples from a cross-sectional observational study.

Freshness

Last updated March 20, 2026.

Geography

General population sample; specific geography not stated.