Mouse Lung Proteomics and Cytokine Data for Millettia Speciosa Asthma Treatment Study

Proteomic and cytokine data from a study investigating the therapeutic effects of Niudali (Millettia speciosa) in an ovalbumin-induced mouse model of allergic asthma. The dataset includes results from high-resolution data-independent acquisition (DIA) lung proteomics and cytokine profiling, identifying 179 differentially expressed proteins. The data was published by Hangrui Yang on figshare under a CC-BY-4.0 license and was last updated in June 2026.

Use Cases

• Identify potential therapeutic protein targets for allergic asthma based on the 179 differentially expressed proteins.
• Investigate the role of the CCL24-eosinophil axis in airway inflammation using cytokine and proteomic profiles.
• Study immunometabolic pathway modulation, such as PPAR signaling and lipid transport, in a disease model.
• Validate findings related to key hub proteins like Alb, Apoe, and Apoa1 in immune regulation and metabolic homeostasis.

Strengths

• Identifies 179 differentially expressed proteins, providing a quantitative molecular profile.
• Integrates proteomic data with cytokine profiling (IgE, IL-4, IL-5, IL-6) for multi-modal validation.
• Data is shared under a permissive CC-BY-4.0 license, allowing for broad reuse.

Limitations

• The dataset is very small at 4.6 KB, indicating limited raw data scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is derived from a specific mouse model, which may limit direct translation to human asthma.

Provenance

Source

figshare, author Hangrui Yang.

Collection Method

Generated from a laboratory study using an ovalbumin-induced mouse model, high-resolution DIA proteomics, and cytokine profiling.

Freshness

Last updated 2026-06-03 07:42:23; freshness should be verified.