MiR-34a Knockout Mouse Model Data for Alzheimer's Disease Neuroinflammation Study

18.1 MB of experimental data from a study investigating the role of microRNA miR-34a in Alzheimer's disease pathogenesis. The dataset includes results from cognitive testing, neuropathology, and bulk RNA-sequencing of hippocampal tissue from transgenic mouse models. It was authored by Junling Yang and last updated on March 17, 2026.

Use Cases

• Train models to identify gene expression signatures associated with interferon-responsive microglia based on bulk RNA-seq results.
• Analyze correlations between cognitive performance (Morris water maze) and amyloid-beta peptide ratios based on the described biochemical assays.
• Investigate the regulatory role of miR 34a on interferon-stimulated gene expression using the in vitro microglia knockdown data.

Strengths

• Data is openly licensed under CC-BY-4.0.
• File size is 18.1 MB, indicating a contained, downloadable dataset.
• Platform tags provide clear domain classification for discovery.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the specific mouse model and methodologies used.

Provenance

Source

figshare

Collection Method

Experimental data generated from a mouse model study, including behavioral assays, immunohistochemistry, and RNA-sequencing.

Time Range

null

Freshness

Last updated 2026-03-17 13:08:22; freshness should be verified.

Geography

null