Pediatric Asthma-Obesity Comorbidity miRNA Profiles from Whole Blood

Harshita Shailesh published a dataset on figshare in 2026 containing circulating microRNA expression profiles from a cross-sectional pediatric study. The data includes profiles from 43 children across four groups: normal weight with asthma, overweight/obese with asthma, overweight/obese without asthma, and normal weight without asthma. Analysis identified seven differentially expressed miRNAs shared across asthma, obesity, and their comorbidity.

Use Cases

• Identify biomarker candidates for asthma-obesity comorbidity based on shared miRNA signatures.
• Investigate molecular pathways like IL-4/IL-13 signaling using miRNA target gene analysis.
• Correlate miRNA dysregulation with clinical parameters like neutrophil counts and lung function.
• Validate potential therapeutic targets for managing asthma in children with obesity.
• Compare miRNA expression patterns between isolated and comorbid disease states.

Strengths

• Data is derived from a controlled study design with four distinct pediatric groups.
• Profiles were generated using the standardized NanoString nCounter platform.
• The dataset is licensed CC-BY-4.0, allowing for broad reuse and sharing.

Limitations

• The dataset is small, with 43 total samples across all groups.
• Column-level documentation is absent; field semantics must be inferred after download.
• The cross-sectional design limits causal inference; authors note validation requires longitudinal studies.

Provenance

Source

figshare

Collection Method

Whole blood samples collected from pediatric cohorts, with miRNA profiles assessed via NanoString nCounter.

Freshness

Last updated 2026-05-13 04:57:56