Prospective Rectal Cancer Study Pathological Response Outcomes from Vietnam

A prospective single-arm study enrolled 101 patients with stage II–III rectal cancer to evaluate total neoadjuvant therapy. The analysis includes pathological complete response and tumor regression grade outcomes for 95 resected patients. The study was conducted at a Vietnamese oncology center and authored by Vo Duc Hieu.

Use Cases

• Analyze the association between treatment regimens (CAPOX or FOLFOX) and pathological complete response (pCR) rate.
• Assess the distribution of tumor regression grades (TRG 0–1) across the cohort of 95 resected patients.
• Evaluate treatment completion rates and reported toxicity profiles from the prospective study data.
• Compare pCR and good regression outcomes from this Vietnamese center to global benchmark studies.

Strengths

• Prospective study design with a defined cohort of 101 enrolled patients.
• Reports specific clinical metrics including a 35.7% pathological complete response (pCR) rate.
• Focus on a resource-limited setting (Vietnam) provides data underrepresented in global literature.

Limitations

• Small sample size of 101 patients limits statistical power for subgroup analyses.
• Single-arm study design lacks a comparative control group for outcome attribution.
• Data is presented in a 173.0 KB PDF, requiring manual extraction for quantitative analysis.

Provenance

Source

Vo Duc Hieu via figshare.

Collection Method

Prospective single-arm clinical study.

Time Range

null

Freshness

Last updated March 2026.

Geography

Vietnamese oncology center.