Preclinical Meta-Analysis of Moringa Oleifera for Peptic Ulcer Disease

This systematic review and meta-analysis consolidates evidence from 11 preclinical studies involving 268 animals to evaluate the therapeutic effect of Moringa oleifera on peptic ulcer disease. It reports a pooled standard mean difference of -1.42 for ulcer index reduction and includes subgroup analyses by dose and comparator.

Use Cases

• Analyze the relationship between Moringa oleifera dose and ulcer index reduction across 11 included studies
• Compare the standard mean difference (SMD) outcomes for high-dose Moringa versus standard drug controls
• Examine heterogeneity (I²) and publication bias results from the meta-analysis methodology
• Review the SYRCLE quality scores, which ranged from 8 to 9, for methodological assessment of included studies

Strengths

• Pooled analysis is based on 11 studies involving 268 animal subjects
• Reports specific quantitative results including a standard mean difference (SMD) of -1.42 with a 95% confidence interval
• Includes subgroup analyses (e.g., by dose and comparator) and sensitivity analyses that resolved heterogeneity

Limitations

• The dataset is a single 8.9 KB document, not a structured data table, limiting computational analysis
• Evidence is solely from preclinical (rodent) studies, with no clinical trial data included
• The review notes methodological heterogeneity among the included primary studies

Provenance

Source

figshare, authored by Saheed Olatunbosun Akiode

Collection Method

Systematic review and meta-analysis of studies from PubMed, CINAHL, Scopus, Web of Science, and Cochrane Library up to August 2025

Time Range

Literature search from database inception to August 2025

Freshness

Last updated March 20, 2026