Mouse Study Data on Ferulic Acid's Preventive Effect for Ulcerative Colitis

A 2026 dataset from figshare by Zheng Zhong. It contains experimental results from a study of 60 male Kunming mice (6–8 weeks old) to ascertain the preventive mechanism of ferulic acid on dextran sulfate sodium-induced ulcerative colitis. Data includes quantified colonic histopathology, inflammatory mediators, antioxidant enzyme activities, and gut microbiota composition from 16S rRNA sequencing.

Use Cases

• Train models to predict inflammatory response based on cytokine levels (IL-1β, IL-6, IL-10, IL-2) and fecal markers (calprotectin, lactoferrin).
• Analyze correlations between antioxidant capacity (SOD, GSH-Px, CAT, T-AOC, MDA) and histological damage scores in colitis.
• Cluster or classify gut microbiota profiles (e.g., Muribaculaceae, Clostridia) associated with treatment groups (Control, DSS, FA+DSS).
• Compare the efficacy of ferulic acid versus prednisone treatment across multiple measured biological endpoints.

Strengths

• Experimental design includes six distinct treatment/control groups (CON, DSS, FA+DSS, FA, Pdn, Pdn+DSS) for comparative analysis.
• Data integrates multiple measurement types: histopathology (HE staining), cytokine ELISA, antioxidant assays, and 16S rRNA gut microbiota sequencing.
• Released under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Row count and specific column names are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a single, controlled mouse study (60 subjects), which may limit generalizability.

Provenance

Source

figshare

Collection Method

Laboratory experiment with 60 male Kunming mice, using techniques including HE staining, transmission electron microscopy, ELISA, and 16S rRNA sequencing.

Time Range

Experimental timeframe not specified; dataset published in 2026.

Freshness

Last updated 2026-04-13 05:48:57; freshness should be verified.

Geography

Not specified; likely a laboratory setting.