Planarian Behavioral Screening Data for Organophosphorus Pesticide Mixtures

Danielle Ireland's dataset from 2026 quantifies the effects of 21 binary mixtures of 7 organophosphorus pesticides on Dugesia japonica planarians. It includes 22 automated readouts on lethality, stickiness, and behavior at days 7 and 12 post-exposure, comparing adult and regenerating organisms. The data was used to evaluate mixture interactions against a Loewe concentration addition model and to correlate behavioral outcomes with acetylcholinesterase inhibition.

Use Cases

• Modeling mixture interactions (additivity, synergism, antagonism) based on 22 behavioral and physiological readouts.
• Comparing neurotoxic susceptibility between adult and developing nervous systems based on data from adult vs. regenerating planarians.
• Correlating behavioral endpoints like 'stickiness' with biochemical markers like acetylcholinesterase inhibition.
• Screening organophosphorus pesticide combinations for high-throughput toxicology studies using an automated platform.

Strengths

• Includes data for 21 binary mixtures of 7 distinct organophosphorus pesticides.
• Provides 22 distinct automated readouts per observation, covering lethality, stickiness, and behavior.
• Compares results across two developmental stages (adult and regenerating) and two time points (days 7 and 12).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (50.6 KB), indicating a limited experimental scope.

Provenance

Source

Danielle Ireland via figshare.

Collection Method

Experimental data from an automated high-throughput screening platform applied to planarian models.

Freshness

Last updated 2026-03-25 22:02:15; freshness should be verified.