Rat Model Data on 2-Methoxyestradiol Effects After Subarachnoid Hemorrhage

A dataset from a figshare study investigating the effects of 2-Methoxyestradiol on neuroinflammation and brain edema in rats following induced subarachnoid hemorrhage. The data includes neurological scores, brain water content, blood-brain barrier permeability measurements, and protein expression levels. Author Qiang Hu published the dataset under a CC-BY-4.0 license, with a last update recorded as 2026-04-27.

Use Cases

• Analyzing the relationship between drug treatment and neurological score improvements based on the described experimental results.
• Modeling the effect of inflammatory factors like IL-1β, IL-6, and TNF-α on brain edema based on the described measurements.
• Investigating correlations between tight junction protein expression (ZO-1, occludin) and blood-brain barrier permeability based on the described assays.
• Studying the inhibition mechanism of HIF-1α, MMP-9, and VEGF pathways in neuroinflammation based on the described western blotting results.

Strengths

• Data is derived from a controlled experimental model with specific interventions and measurement timepoints described.
• Includes multiple biological endpoints such as neurological function, brain water content, and molecular protein levels.
• Published under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Row count is unknown, which may limit suitability assessment for statistical modeling.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset title includes 'RETRACTED', which may indicate issues with the underlying study's validity.

Provenance

Source

figshare, author Qiang Hu

Collection Method

Experimental data from a rat endovascular puncture model of subarachnoid hemorrhage, with assays including immunofluorescence, ELISA, and western blotting.

Time Range

Measurements taken at 24 hours after surgery.

Freshness

Last updated 2026-04-27 13:30:28; freshness should be verified.

Geography

Laboratory study; geographic location of the research is not specified.