Mouse Model Data on Stereoselective Nicotine Effects in Parkinson's Disease

A research data sheet detailing the stereoselective effects of nicotine enantiomers on the gut-brain axis in a mouse model of Parkinson's disease. The dataset was authored by Ruixia Liu and last updated on May 13, 2026. It contains results from a study comparing S-nicotine and R-nicotine on motor function, neuroinflammation, and gut microbiota composition.

Use Cases

• Analyze dose-dependent neuroprotective effects based on comparisons of S-nicotine and R-nicotine
• Model correlations between gut microbiota composition and motor function improvements based on Akkermansia enrichment data
• Investigate the relationship between intestinal barrier integrity and neuroinflammatory responses described in the results

Strengths

• The description provides specific, quantitative findings such as effective doses of 1 mg/kg for S-nicotine and 3 mg/kg for R-nicotine
• Results detail multiple measured outcomes including motor deficits, dopaminergic neuronal loss, and inflammatory responses
• The dataset is licensed under CC-BY-4.0, allowing for broad reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The data is contained in a 2.6 MB DOCX file, which may require parsing to extract structured information

Provenance

Source

Ruixia Liu via figshare

Collection Method

Systematic comparison of nicotine enantiomers in an MPTP-induced mouse model of Parkinson's disease.

Freshness

Last updated 2026-05-13 04:51:44; freshness should be verified