Meta-Analysis of Brain Alterations in Alzheimer's Disease with Depression

1973 participants from 30 neuroimaging studies were analyzed to compare brain structure and function in Alzheimer's Disease and Mild Cognitive Impairment patients with and without depression. The coordinate-based meta-analysis identified decreased gray matter volume in the right hippocampus and altered neural activity in frontal and temporal gyri. Author Yang Du synthesized studies from PubMed, Embase, PsycINFO, and Cochrane Library spanning 1995 to 2025.

Use Cases

• Identify brain regions like the right hippocampus showing decreased gray matter volume (GMV) in patients with comorbid depression.
• Compare neural activity patterns in the right superior frontal gyrus (SFG) between ADD and ADND patient subgroups.
• Analyze modality differences in structural (GMV) versus functional (neural activity) alterations for MCID versus MCIND groups.
• Map coordinate-based meta-analysis results for the left inferior temporal gyrus (ITG) to explore spatial convergence of findings.

Strengths

• Aggregates data from 30 studies with a total sample of 1973 participants.
• Provides multimodal analysis comparing both structural (GMV) and functional (neural activity) neuroimaging findings.
• Includes subgroup analysis for 520 ADD, 297 MCID, 748 ADND, and 408 MCIND patients.

Limitations

• Data is presented as a synthesized meta-analysis document (DOCX), not as a structured, queryable dataset.
• Underlying participant-level neuroimaging data or original study coordinates are not provided.
• The 3.4 MB file size indicates a text summary, limiting direct computational analysis.

Provenance

Source

Meta-analysis of studies from PubMed, Embase, PsycINFO, and the Cochrane Library.

Collection Method

Coordinate-based meta-analysis using Activation Likelihood Estimate (ALE) on neuroimaging study results.

Time Range

Studies published from December 1995 to December 2025.

Freshness

Last updated March 2026, with literature coverage through December 2025.

Geography

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