Case Report: Surgery-Enabled Precision Oncology in an MSI-High Pulmonary Artery Sarcoma

A 26.5 KB PDF case report authored by Akina Nigi, last updated on 2026-04-30. It details the management of a rare vascular tumor in a 44-year-old man with Lynch syndrome, focusing on molecularly guided immunotherapy and long-term survival. The report is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Study long-term outcomes of immunotherapy in rare sarcomas based on the reported 65+ months of disease stability.
• Analyze the role of comprehensive genomic profiling in hereditary cancer syndromes based on the identified pathogenic MLH1 variant.
• Investigate treatment strategies for MSI-high, TMB-high tumors with low PD-L1 expression based on the response to ipilimumab, nivolumab, and pembrolizumab.
• Review surgical approaches for aggressive tumors based on the described right pneumonectomy under ECMO support.

Strengths

• Report includes specific clinical details: patient age (44), survival duration (over 65 months), and identified genetic variant (MLH1).
• The case is well-documented with a clear narrative of diagnosis, treatment, and molecular findings.
• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is a single case report (26.5 KB), representing a sample size of one, which limits generalizability.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last updated 2026-04-30 04:16:30; freshness should be verified.

Provenance

Source

figshare, authored by Akina Nigi.

Collection Method

Likely a clinical case report documenting patient history, diagnostics, and treatment.

Freshness

Last updated 2026-04-30 04:16:30.