Systematic Review on Non-IgE Cow's Milk Allergy with Multi-Omics Corroboration

A systematic review synthesizing evidence from 39 studies on non-IgE-mediated cow's milk allergy in infants aged 0–3 years. The review includes an integrative analysis of publicly available single-cell RNA sequencing datasets from pediatric intestinal biopsies. The PDF document was authored by Wei Kong, licensed under CC-BY-4.0, and last updated on April 14, -2026.

Use Cases

• Investigating the AhR–TLR4 axis in non-IgE-mediated allergy based on the described mechanistic pathway
• Evaluating the Bifidobacterium to Enterobacteriacea (B/E) ratio as a predictive biomarker for allergy persistence
• Analyzing single-cell RNA-seq data for TLR4 co-receptor expression and NLRP3 inflammasome activation in intestinal epithelial cells
• Assessing the potential of synbiotic interventions for symptom resolution based on the reported 67% outcome

Strengths

• Evidence synthesis from 39 physician-confirmed studies following PRISMA guidelines
• Includes integrated analysis of publicly available single-cell RNA sequencing datasets
• Reports specific predictive metrics, including a hazard ratio of 1.9 and an AUC of 0.82 for the B/E ratio

Limitations

• The dataset is a 348.7 KB PDF document; the underlying raw data or column definitions are not provided
• Row count and data structure for the integrated omics data are unknown
• Freshness should be verified as the last update date is in the future (2026)

Provenance

Source

Wei Kong, published on figshare

Collection Method

Systematic review with integrated multi-omics analysis

Time Range

Studies focus on infants aged 0–3 years

Freshness

Last updated 2026-04-14 05:39:04

Geography

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