Meta-Analysis of Continuous Glucose Monitoring on Neonatal Outcomes

A systematic review and meta-analysis of 17 randomized controlled trials, comprising data from 2,349 pregnant women with diabetes, published from database inception through February 5, 2026. The study compares continuous glucose monitoring (CGM) to standard self-monitoring (SMBG) on neonatal outcomes like NICU admission, LGA, SGA, neonatal hypoglycemia, and hyperbilirubinemia. It was authored by Xiaojun Lai and reports pooled risk ratios with 95% confidence intervals.

Use Cases

• Compare pooled risk ratios for NICU admission between CGM and SMBG groups to assess intervention effectiveness.
• Analyze the association between CGM use and the incidence of large for gestational age (LGA) versus small for gestational age (SGA).
• Evaluate heterogeneity metrics (I2) across outcomes like neonatal hypoglycemia and hyperbilirubinemia to assess study consistency.
• Use the reported risk ratios and confidence intervals for neonatal outcomes to inform clinical decision models or cost-effectiveness analyses.

Strengths

• Includes data from 17 randomized controlled trials, a standard for clinical evidence.
• Aggregates results from 2,349 participants, providing a substantial sample for meta-analysis.
• Reports specific statistical measures including risk ratios, 95% confidence intervals, P-values, and I2 heterogeneity scores for each outcome.

Limitations

• The dataset is a 16.5 KB document summarizing results, not the raw trial-level or patient-level data, limiting analytical depth.
• The temporal coverage ends in February 2026, which is a future date, suggesting the description may contain a typographical error or projection.
• Findings are based on aggregated study results; individual patient demographics or covariates are not available for subgroup analysis.

Provenance

Source

figshare, authored by Xiaojun Lai.

Collection Method

Systematic review and meta-analysis of RCTs from PubMed, Embase, Scopus, and Cochrane Library.

Time Range

Database inception through February 5, 2026.

Freshness

Last updated March 25, 2026.