Meta-Analysis of HIF-1α and Glycemic Parameters in Type 2 Diabetes

A systematic review and meta-analysis of 36 observational studies involving 5,979 patients with type 2 diabetes. The data synthesizes associations between peripheral blood HIF-1α protein levels and key glycemic outcomes. The analysis was conducted by Yi Su and published on figshare in April 2026.

Use Cases

• Analyze associations between HIF-1α levels and fasting plasma glucose based on the meta-analysis results
• Model relationships between HIF-1α and glycated hemoglobin based on the reported mean differences
• Investigate the link between HIF-1α and fasting insulin levels based on the aggregated study data
• Assess the correlation between HIF-1α and HOMA-IR scores based on the pooled effect estimates

Strengths

• Aggregates data from 36 studies with a total sample size of 5,979 patients
• Includes results from a systematic search of eight major databases, including PubMed and CNKI
• Provides specific mean difference estimates with 95% confidence intervals for four glycemic parameters

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect geographic bias inherent to the included studies, as subgroup analysis indicated location modified associations

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of observational studies from eight databases.

Time Range

Studies searched from inception to July 28, 2025.

Freshness

Last updated 2026-04-10 06:02:06; freshness should be verified