TSLP Cytokine Levels in Abdominal Aortic Aneurysm Patients and Controls

Serum thymic stromal lymphopoietin (TSLP) cytokine measurements from 632 abdominal aortic aneurysm patients and 24,036 controls in the UK Biobank. The dataset supports a research paper by Qi Zheng, published in April 2026, investigating TSLP's role in AAA pathogenesis via macrophage polarization.

Use Cases

• Analyze the association between serum TSLP levels and AAA patient status using the 24,668 clinical samples.
• Investigate TSLP's effect on macrophage polarization states (M1 vs. M2) as profiled by mass cytometry (CyTOF).
• Validate transcriptomic findings from bulk RNA sequencing, such as cytokine-cytokine receptor interaction and chemokine signaling pathways.
• Correlate in vivo model outcomes (AAA severity from elastase and calcium phosphate models) with pharmacological TSLP manipulation data.

Strengths

• Clinical cohort includes 24,668 individuals (632 cases, 24,036 controls).
• Multi-level validation integrates human serum data, two murine models, CyTOF, RNA-seq, and in vitro assays.
• Data is recent, with a last update in April 2026.

Limitations

• Dataset is a single 184 KB PDF; raw numerical or columnar data is not directly provided.
• Sample size for the AAA patient cohort (632) is modest relative to the control group.
• Geographic coverage is limited to the UK Biobank population.

Provenance

Source

UK Biobank for human serum data; experimental murine models and assays from the research study.

Collection Method

Integrated analysis of clinical epidemiology, in vivo models, mass cytometry, RNA sequencing, and in vitro mechanistic assays.

Time Range

null

Freshness

Last updated 2026-04-07.

Geography

United Kingdom (UK Biobank).