Thyroid Autoimmunity and Cardiometabolic Phenotype in Women with Polycystic Ovary Syndrome

A cross-sectional analysis of 1,300 women with confirmed polycystic ovary syndrome (PCOS) evaluated the clinical relevance of thyroid autoimmunity for cardiometabolic and androgenic severity. The dataset, authored by Natalia Piórkowska and licensed under CC-BY-4.0, was last updated on 2026-05-01. It contains results from age-adjusted Firth logistic regression models assessing associations between three definitions of thyroid autoimmunity and endpoints like triglyceride-to-HDL cholesterol ratio.

Use Cases

• Assessing the association between thyroid autoimmunity and triglyceride-to-HDL cholesterol ratio based on the primary endpoint definition.
• Evaluating links between thyroid antibody positivity and non-HDL cholesterol levels based on secondary endpoint data.
• Investigating relationships between thyroid autoimmunity definitions and impaired glucose tolerance results from oral glucose tolerance tests.
• Conducting sensitivity analyzes on cardiometabolic associations by restricting data to euthyroid participants as described.

Strengths

• Includes data from 1,300 women with confirmed PCOS, providing a substantial cohort size.
• Uses pre-specified, rigorous statistical methods including age-adjusted Firth logistic regression and false discovery rate correction.
• Examines thyroid autoimmunity under three distinct, a priori definitions (TAI_A, TAI_B, TAI_C).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small in file size (93.7 KB), indicating limited raw data scope.

Provenance

Source

figshare, authored by Natalia Piórkowska.

Collection Method

Cross-sectional study analysis of a source dataset of women with PCOS.

Freshness

Last updated 2026-05-01 04:14:19; freshness should be verified.