Mouse Muscle Transcriptome Data on High-Fat Diet and Exercise Intervention

RNA sequencing data from a mouse study investigating the effects of an 8-week moderate-intensity continuous training intervention on high-fat diet-induced muscle wasting. The dataset was published by Weihao Hong on figshare in March 2026. It contains transcriptomic profiles from gastrocnemius muscle tissue.

Use Cases

• Identify differentially expressed genes related to muscle atrophy based on the described Foxo1, Fbxo32, and Trim63 markers.
• Analyze transcriptional programs for lipid metabolism based on the description of enhanced fatty acid uptake, trafficking, and β-oxidation.
• Perform functional enrichment analysis on pathways mentioned in the description, such as FoxO, PI3K–Akt, MAPK, and insulin signaling.
• Investigate gene expression changes associated with biological processes like angiogenesis and calcium signaling as noted in the study.

Strengths

• Data is associated with a detailed, peer-reviewed study methodology described in the abstract.
• Dataset is openly available under a CC-BY-4.0 license.
• File size is 13.2 KB, indicating a focused and manageable dataset for initial analysis.

Limitations

• Row count and column definitions are unknown, which limits suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a specific mouse model study; applicability to other species or conditions is unknown.

Provenance

Source

figshare, author Weihao Hong.

Collection Method

RNA sequencing of mouse gastrocnemius muscle tissue from an experimental study.

Freshness

Last updated 2026-03-18 07:34:55.