Mouse Brain Transcriptomic Data for High-Altitude Cerebral Injury and Oxygen Therapy

RNA sequencing data from a mouse model of high-altitude cerebral injury, comparing normobaric and hyperbaric oxygen treatments. The dataset, shared by Xiaojie Hu on figshare in April 2026, includes results from pathway analysis and targeted validation of oxidative stress and inflammation markers. It is a 43.8 KB PDF file containing supplementary data for the associated research paper.

Use Cases

• Analyze transcriptomic changes in response to high-altitude hypoxia based on RNA-seq results.
• Compare the molecular effects of different oxygen therapies (NBO vs. HBO) based on pathway enrichment data.
• Validate findings related to oxidative stress markers (SOD, MDA, GSH, NO) and inflammatory cytokines (IL-1β, IL-6, TNF-α).
• Investigate pathway modulation (PI3K–AKT, NF-κB, TLR4) in a controlled animal model of cerebral injury.

Strengths

• Data is associated with a detailed experimental protocol using a mouse model exposed to 7,000 m simulated altitude for 3 days.
• Includes multi-modal validation data from RNA-seq, Western blot, immunofluorescence, and ELISA mentioned in the description.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 43.8 KB file size suggests the dataset is a summary or supplementary table, not the full raw sequencing data.

Provenance

Source

figshare, author Xiaojie Hu.

Collection Method

Generated from a controlled laboratory study using a hypobaric hypoxia chamber and subsequent molecular analyses.

Time Range

Experimental timeframe is not specified.

Freshness

Last updated 2026-04 13 05:49:15; freshness should be verified.

Geography

Laboratory study; geographic origin is not specified.