UHR as a Systemic Sensor of Cumulative Heat Exposure and Subclinical Cardiovascular Injury

A retrospective cross-sectional study of 64,088 adults from Sichuan, China, investigating the relationship between cumulative heat exposure and subclinical cardiovascular injury. The research was authored by Tao Cheng and the dataset was last updated on May 7, 2026. It quantifies heat exposure using a Cumulative Excess Heat Wave Index and assesses injury via biomarkers like lipid remodeling markers, the Atherogenic Index of Plasma, and myocardial injury enzymes.

Use Cases

• Modeling the dose-response relationship between cumulative heat exposure and subclinical cardiovascular injury markers.
• Conducting causal mediation analysis to identify metabolic-inflammatory pathways, such as the Uric Acid-to-HDL Cholesterol Ratio (UHR) nexus.
• Performing subgroup analyses to assess heightened vulnerability in populations like older adults and hypertensive individuals.

Strengths

• Based on a large-scale population of 64,088 adults.
• Employs a novel Cumulative Excess Heat Wave Index (CEHWI) for quantifying thermal burden.
• Analyzes a progressive cascade of cardiovascular injury biomarkers.

Limitations

• The dataset description does not specify column names or the number of rows.
• The data is contained in a 7.7 KB PDF file, suggesting limited raw data scope.
• Geographic coverage is limited to Sichuan, China, which may limit generalizability.

Provenance

Source

figshare

Collection Method

Large-scale, population-based retrospective cross-sectional study.

Freshness

Last updated 2026-05-07 05:42:44

Geography

Sichuan, China