Whole-Exome Sequencing Data for Semen Quality in a Russian Multiethnic Population

A Russian study presents whole-exome sequencing data from 157 male samples to investigate genetic factors associated with semen quality. The dataset includes three ethnic groups—Slavs (59), Buryats (49), and Yakuts (49)—and two semen quality groups: pathozoospermia (95) and normospermia (62). It was authored by Semyon Kolmykov and last updated on April 9, 2026.

Use Cases

• Identify genetic variants associated with impaired semen quality based on whole-exome sequencing data.
• Compare genetic associations with fertility across different ethnic groups (Slavs, Buryats, Yakuts).
• Prioritize candidate genes for male infertility by analyzing polymorphisms in testis-expressed genes.
• Validate potential SNP markers for pathozoospermia in larger population samples.

Strengths

• Includes 157 whole-exome sequenced samples with defined ethnic and semen quality groups.
• Identifies nine specific SNP markers (e.g., rs6971091, rs557806) in seven candidate genes for subsequent verification.
• Samples are negative for complete AZF microdeletions, providing a focused genetic cohort.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 3.7 MB file size suggests a small dataset, potentially containing summary or variant-level data rather than raw sequences.

Provenance

Source

figshare, authored by Semyon Kolmykov.

Collection Method

Whole-exome sequencing performed on 157 samples, with variant calling and filtering according to GATK Best Practices. Association analysis used the χ2 test.

Freshness

Last updated 2026-04-09 03:03:40; freshness should be verified.

Geography

Russian Federation, specifically samples from Slavic, Buryat, and Yakut ethnic groups.