Wogonoside Effects on Corneal Epithelial Cells Under Hyperosmotic Stress

Experimental data from a study investigating the protective effects of the flavonoid Wogonoside on human corneal epithelial cells under hyperosmotic stress. The dataset, shared by Yuan Zhong under a CC-BY-4.0 license, includes results from network pharmacology, molecular docking, and cellular assays measuring viability, apoptosis, and inflammatory markers. It was last updated on 2026-05-04.

Use Cases

• Analyze the relationship between PI3K/AKT signaling pathway activity and cell viability based on experimental validation results.
• Study the anti-inflammatory effects of Wogonoside based on measured levels of IL-1β, IL-6, and MMP-9.
• Validate network pharmacology predictions for drug-target interactions based on molecular docking and CETSA data.
• Investigate hyperosmotic stress-induced apoptosis in corneal cells based on apoptosis assessment data.

Strengths

• Includes multi-method validation combining network pharmacology, molecular docking, and cellular assays.
• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse.
• Specific experimental conditions are described, such as hyperosmotic medium at 500 mOsm and inhibitor concentrations.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 8.1 MB, potentially limiting the scope of included data.

Provenance

Source

figshare, author Yuan Zhong.

Collection Method

Generated from in vitro experiments on transformed human corneal epithelial cells (HCE-T cells).

Time Range

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Freshness

Last updated 2026-05-04 04:24:23; freshness should be verified.

Geography

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