Xinnaoxin Tablets: Mouse Model Data on High-Altitude Cardiac Injury Mechanisms

A research article from figshare, authored by Zhihui Wang and last updated on 2026-05-28, details a study on Xinnaoxin tablets for high-altitude polycythemia and cardiac injury. The 185.7 KB PDF likely contains experimental results from a hypobaric hypoxia mouse model, including blood parameters, cytokine levels, and Western blot analyses. The dataset is licensed under CC-BY-4.0.

Use Cases

• Analyzing drug effects on blood parameters like red blood cell count and hemoglobin based on described experimental assessments.
• Studying the modulation of signaling pathways such as NF-κB and MAPK based on Western blot analysis results mentioned.
• Investigating the relationship between oxidative stress markers (MDA, SOD) and cardiac injury based on the described methodology.
• Modeling the inhibition of bone marrow CD71+ cell populations as a measure of 'ineffective erythropoiesis' based on the results.

Strengths

• The description provides a detailed methodological breakdown of in-vivo and molecular analyses.
• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse.
• The study employs a multi-level analysis strategy combining systems pharmacology and experimental validation.

Limitations

• The dataset is a 185.7 KB PDF, suggesting it is a research article or supplementary file rather than a structured data table.
• Row count and column-level documentation are absent; data semantics must be inferred from the text.
• The geographic origin and specific time range of the underlying experimental data are not specified.

Provenance

Source

figshare, author Zhihui Wang.

Collection Method

Data was generated from a hypobaric hypoxia mouse model using techniques including UPLC-Q-TOF-MS, complete blood counts, hemorheology, flow cytometry, and Western blot.

Freshness

Last updated 2026-05-28 04:53:04; freshness should be verified.