ZFP36L1 Antiviral Role and Autophagy in Murine Norovirus Infection

Murine norovirus 1 (MNV-1) infection data from a study investigating the RNA-binding protein ZFP36L1. The 50.8 KB PDF, authored by Malabika Bhowmik and last updated in April 2026, details how ZFP36L1 overexpression suppressed viral replication and reduced autophagy markers like ATG13 and LC3-I to LC3-II conversion. Results suggest ZFP36L1-mediated autophagy suppression contributes to antiviral effects against norovirus.

Use Cases

• Study the antiviral mechanism of ZFP36L1 based on overexpression and knockdown experiments described.
• Analyze the relationship between norovirus replication and autophagy based on measured markers like ATG13 and LC3 conversion.
• Investigate pharmacological modulation of autophagy using rapamycin or 3-methyladenine in the context of viral infection as described.
• Examine gene expression changes in autophagy-related pathways, such as ATG13, Beclin-1, and Bcl-2, following ZFP36L1 manipulation.

Strengths

• Data is openly licensed under CC-BY-4.0 for reuse.
• The study provides a specific molecular mechanism linking ZFP36L1, autophagy suppression, and norovirus replication.

Limitations

• The dataset is a single 50.8 KB PDF document, indicating a very limited data scope.
• Row count and column-level documentation are absent; data semantics must be inferred from the paper.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from virology and molecular biology assays.

Freshness

Last updated 2026-04-21 09:23:41; freshness should be verified.