Serum Biomarkers in Middle-Aged Male Rats with Maternal Separation History

A dataset from a 2026 study on the systemic effects of early-life stress in rodents. The data, authored by Pratik R. Chaudhari and shared on figshare, contains serum measurements from middle-aged male rats subjected to maternal separation. It includes levels of corticosterone, trophic factors, oxidative stress markers, lipid profiles, and advanced glycation end-products.

Use Cases

• Modeling the relationship between early-life stress and serum corticosterone levels based on the described measurements.
• Analyzing correlations between oxidative stress markers (Ox-LDL, SOD, catalase) and metabolic dysregulation (triglycerides, cholesterol) as described.
• Investigating the accumulation of advanced glycation end-products (AGEs, MGO, sRAGE) as a potential mechanistic link to aging processes mentioned in the study.

Strengths

• Data is derived from a controlled animal model study focusing on a specific biological mechanism.
• The description details a multi-faceted analysis covering hormonal, metabolic, oxidative, and glycation pathways.
• Dataset is openly licensed under CC-BY-4.0 for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (1.4 MB) and its scope is limited to a single experimental cohort.

Provenance

Source

figshare

Collection Method

Experimental data collected from a rodent model study.

Time Range

Data collection timeframe is not specified.

Freshness

Last updated 2026-05-04 04:24:32; freshness should be verified.

Geography

Geographic origin of the study is unknown.