Meta-Analysis and Expression Profiling of DNA Repair Gene Polymorphisms in Leukemia

Data Sheet 3_A meta-analysis and expression profiling of DNA repair gene polymorphisms in leukemia.docx is a 206.8 KB document authored by Honghui Ye and last updated on April 23, 2026. It summarizes a meta-analysis of 54 studies investigating associations between DNA repair gene polymorphisms and leukemia risk, along with gene expression analyses across leukemia subtypes.

Use Cases

• Assessing genetic risk associations for leukemia based on meta-analysis results for polymorphisms like XPD Lys751Gln and XRCC1 Arg399Gln.
• Investigating subtype-specific expression patterns of DNA repair genes mentioned in the analysis.
• Identifying potential biomarkers for leukemia risk stratification based on the highlighted polymorphisms and expression alterations.

Strengths

• Includes results from a meta-analysis of 54 studies, providing a synthesized evidence base.
• Analyzes multiple specific polymorphisms (e.g., ERCC1 C118T, XPD Asp312Asn, XRCC1 Arg194Trp) and their associations across genetic models.
• Combines meta-analysis with gene expression profiling from three datasets (Leukemia DB, GEPIA2, BloodSpot).

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a 206.8 KB DOCX file, indicating a limited scope likely containing summary results rather than raw data.

Provenance

Source

figshare, author Honghui Ye.

Collection Method

Systematic literature search of PubMed, Web of Science, Scopus, and Cochrane Library, combined with gene expression analysis in public datasets.

Time Range

Literature search conducted until December 3, 2025.

Freshness

Last updated 2026-04-23 04:21:49; freshness should be verified.

Geography

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