Standardized Rat Model of Maxillary Anterior Periodontal Soft Tissue Defect

Ruoxuan Huang published a research paper in 2026 detailing a standardized animal model for periodontal soft tissue defects. The 7.3 MB PDF describes a method for creating a reproducible 4 x 2 mm defect in rats to evaluate graft materials. The study includes clinical observations and histological analyses of healing patterns.

Use Cases

• Benchmarking soft tissue graft material performance based on the described standardized defect model.
• Studying biological responses like angiogenesis and immune response during tissue regeneration as detailed in the methods.
• Comparing healing patterns of autografts versus xenografts based on the described clinical and histological evaluation.

Strengths

• The model is described as standardized, minimally invasive, and reproducible with low complication rates.
• Includes a specific defect size (4 x 2 mm) and details on evaluation methods like H&E and Masson's trichrome staining.
• Released under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is a single 7.3 MB PDF document; the underlying raw experimental data is not provided.
• Row count and column-level documentation are absent; data must be extracted manually from the paper.
• The model is specific to rat maxillary anterior labial regions, which may limit direct translational inferences.

Provenance

Source

figshare

Collection Method

Experimental research involving surgical defect creation and histological analysis in rats.

Time Range

The study was published in 2026.

Freshness

Last updated 2026-04-20 05:23:15.

Geography

The research likely originates from an academic or research institution, though the specific organization is unknown.