Data Sheet 3_ALDH1A1-dopaminergic gene co-expression in human substantia nigra: meta-analy

A meta-analysis of gene expression correlations across seven independent human substantia nigra microarray datasets (n = 156; 70 controls, 86 PD). The dataset, created by Drake H. Harbert and last updated in May 2026, reports pooled correlation estimates between ALDH1A1 and dopaminergic pathway genes in Parkinson's disease and control samples.

Use Cases

• Meta-analyzing gene co-expression changes in Parkinson's disease based on correlation coefficients from seven datasets.
• Investigating the relationship between ALDH1A1 expression and dopaminergic pathway genes like TH, DDC, and SLC18A2.
• Assessing the selectivity of ALDH1A1 correlation attenuation in disease using the provided permutation test results.
• Validating findings on cell type enrichment changes in the substantia nigra using marker gene-based scoring.

Strengths

• Aggregates data from seven independent human substantia nigra microarray datasets, totaling 156 samples.
• Reports specific correlation changes, such as a mean Δr of -0.336 for ALDH1A1-dopamine gene pairs in PD.
• Applies random-effects meta-analysis with DerSimonian-Laird estimation and permutation testing (n=5,000) for statistical rigor.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (2.9 KB), indicating it contains summary statistics rather than raw expression data.
• Freshness should be verified as the last update date is in the future (2026-05-19).

Provenance

Source

Gene Expression Omnibus (GEO) via figshare

Collection Method

Meta-analysis of gene expression correlations from seven independent human SN microarray datasets.

Freshness

Last updated 2026-05-19 05:30:32