Axolotl Immunoglobulin Loci Characterization from Improved Genome Assembly

Stephanie Saint Remy-Hernández presents an updated genomic characterization of immunoglobulin loci in the axolotl (Ambystoma mexicanum) based on the UKY_AmexF1_1 genome assembly. The dataset, last updated in March 2026, compares immunoglobulin heavy (IGH) and lambda (IGL) loci between this new assembly and the previous AmbMex60DD version, noting structural variations. It is a 46.8 KB Excel file shared under a CC-BY-4.0 license on figshare.

Use Cases

• Comparative genomics analysis based on the described IGH and IGL locus structures.
• Studying intraspecies structural variation in immune gene loci based on the findings between two genome assemblies.
• Gene model refinement for immunoglobulin genes based on RNA-Seq data from multiple axolotl tissues mentioned in the methods.
• Investigating synteny and gene orientation in immunoglobulin loci based on the mapping to chromosome 13q.

Strengths

• Data is derived from an improved genome assembly (UKY_AmexF1_1) with only 220 unmapped scaffolds.
• Manual curation and RNA-Seq data from spleen, liver, lung, heart, and gill tissues were used for gene model refinement.
• Specific genomic coordinates are provided (IGH locus at 350–364 Mbp on chromosome 13q).

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (46.8 KB), indicating limited scope, likely containing summary annotations rather than raw sequence data.

Provenance

Source

figshare, author Stephanie Saint Remy-Hernández.

Collection Method

Alignment-based annotation and manual curation performed on the UKY_AmexF1_1 genome assembly, using previously annotated sequences and RNA-Seq data.

Time Range

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Freshness

Last updated 2026-03-17 13:06:57.

Geography

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