Data Sheet 3_Anti-PD-1 blockade reverses low-intensity electric stimulation-driven pancrea

A research data sheet from a study investigating the effects of low-intensity electric stimulation (LIES) and anti-PD-1 blockade on pancreatic ductal adenocarcinoma (PDAC) in mouse models. The study utilized orthotopic PDAC models, in vitro assays, and profiling techniques including flow cytometry, immunofluorescence, and single-cell RNA sequencing. The dataset was authored by Lingman Jiang and last updated on 2026-05-19.

Use Cases

• Analyzing tumor immune microenvironment remodeling based on flow cytometry and multicolor immunofluorescence data mentioned in the description
• Investigating epithelial-mesenchymal transition (EMT) and cell migration based on in vitro assays under varying electric fields
• Studying macrophage polarization and CD8+ T cell activation based on single-cell RNA sequencing (scRNA-seq) results
• Exploring the JAK2-STAT3 pathway activation and PD-L1 expression based on bulk RNA sequencing analysis

Strengths

• Data is associated with a study using multiple profiling techniques, including scRNA-seq, flow cytometry, and immunofluorescence.
• The dataset is openly available under a CC-BY-4.0 license.
• The study utilized orthotopic PDAC mouse models, which are mentioned as a first-time application for evaluating LIES immune modulation.

Limitations

• The primary data file is a 845.2 KB PDF, which likely contains a summary or article rather than raw, structured data tables.
• Column-level documentation and sample data are unavailable, making field semantics and data structure unknown.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare

Collection Method

Data generated from orthotopic PDAC mouse models treated with LIES and anti-PD-1 blockade, with analysis via in vitro assays, flow cytometry, immunofluorescence, and RNA sequencing.

Freshness

Last updated 2026-05-19 05:40:18; freshness should be verified.