Assessing Translational Relevance of Molecular Pathways in Spontaneous Lupus Mouse Models

María Rivas-Torrubia published a dataset on figshare in May 2026. It contains molecular data from four spontaneous lupus mouse models (MRLlpr/lpr, NZB/W, BXSB.Yaa, Tlr7.Tg6) and the human PRECISESADS SLE cohort. The data includes transcriptome sequencing from blood, spleen, and kidney, flow cytometry, and cytokine and autoantibody measurements across four time points.

Use Cases

• Compare molecular pathway dysregulation between mouse models and human SLE based on transcriptome sequencing data.
• Analyze the dynamics of immune signatures over time based on longitudinal data from four time points.
• Identify model-specific immune cell signatures relevant to early disease processes based on flow cytometry and cytokine measurements.
• Evaluate the translational relevance of specific mouse models for studying interferon responses or T/B cell depletion mentioned in the results.

Strengths

• Data integrates longitudinal molecular profiles from four distinct mouse models and a human cohort.
• Includes multiple data modalities: transcriptome sequencing, flow cytometry, and plasma cytokine/autoantibody measurements.
• Dataset is 5.3 MB in size and available under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Transcriptome sequencing, flow cytometry, and plasma assays performed on mouse models; integration with human cohort data from PRECISESADS.

Freshness

Last updated 2026-05-13 05:58:15; freshness should be verified.