Meta-Analysis of PCOS and Metabolic Syndrome in Adolescents

Yuhui Tu's systematic review and meta-analysis synthesizes data from 13 observational studies involving 1,789 participants (1,005 with PCOS and 784 controls). It quantifies the association between polycystic ovary syndrome and metabolic syndrome in adolescents aged 10-20 years, reporting pooled odds ratios and weighted mean differences for key metabolic components.

Use Cases

• Analyze the pooled odds ratio of 2.61 for metabolic syndrome risk in adolescents with PCOS compared to controls.
• Compare weighted mean differences for specific metabolic components like waist circumference (3.23 cm), systolic blood pressure (3.80 mmHg), and triglycerides (5.76 mg/dL) between PCOS and control groups.
• Examine the composition of the underlying evidence base from 13 studies, including 5 cross-sectional, 6 case-control, and 2 cohort study designs.

Strengths

• Analysis is based on a synthesized sample of 1,789 participants from 13 distinct observational studies.
• Results provide specific quantitative metrics, including an odds ratio of 2.61 for metabolic syndrome and weighted mean differences for three key metabolic components.
• The systematic review methodology included searches across multiple major databases (PubMed, Embase, Cochrane Library, Web of Science) up to September 2025.

Limitations

• The underlying data is aggregated from secondary studies; original patient-level records or raw measurements are not available.
• The dataset is a 20.2 MB DOCX file containing textual analysis, not a structured table suitable for direct computational analysis.
• Findings are specific to the adolescent population (aged 10-20 years) and may not generalize to other age groups.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of published observational studies.

Time Range

Studies published up to September 2025.

Freshness

null

Geography

null