Clinical Predictors of BRCA1/2 Variants in High-Risk Chinese Breast Cancer Patients

A clinical dataset of 1,204 high-risk breast cancer patients from Zhejiang Cancer Hospital in eastern China, collected between 2017 and 2021. It was created by Wei Gu to develop a prediction model for germline BRCA1/2 pathogenic or likely pathogenic (P/LP) variant carrier status. The dataset includes clinical predictors such as histology, molecular subtype, age, and family history.

Use Cases

• Training a logistic regression model to predict BRCA1/2 P/LP carrier status based on clinical features like histology and molecular subtype.
• Validating the association between triple-negative breast cancer (TNBC) and BRCA1/2 variant prevalence in a high-risk Chinese cohort.
• Conducting decision curve analysis to evaluate the net clinical benefit of a targeted genetic testing strategy.
• Performing bootstrap internal validation to assess the robustness of a clinical prediction model.

Strengths

• Includes 1,204 patient records from a high-risk clinical cohort, described as the largest such cohort with BRCA1/2 variant information in mainland China.
• Model performance metrics are provided, including an AUC of 0.758 and a Brier score of 0.071.
• Missing data was addressed using a specific imputation method (Multiple Imputation by Chained Equations).
• Dataset is licensed under CC-BY-4.0, facilitating open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying clinical data is unknown, which may limit suitability assessment.
• Data is from a single hospital in eastern China, which may limit generalizability to other populations.

Provenance

Source

Zhejiang Cancer Hospital, eastern China.

Collection Method

Clinical data collection and targeted NGS for BRCA1/2 on blood samples, with variant classification by ClinVar and ACMG-AMP guidelines.

Time Range

2017–2021

Freshness

Last updated 2026-06-02 04:21:29; freshness should be verified.

Geography

Eastern China