Structural and Functional Brain Connectivity in ALS Patients

A multimodal connectomic analysis of Amyotrophic Lateral Sclerosis integrates cortical thickness-based structural covariance networks, diffusion MRI tractography, and resting-state and task-based functional MRI. The study employs a 104-node parcellation scheme based on the Desikan-Killiany atlas to examine structure-function coupling and network reorganization in ALS patients versus matched controls.

Use Cases

• Analyze cross-modal structure-function correspondence using ROI-wise correlation analyses on cortical covariance and diffusion-derived white matter connectivity data.
• Derive graph-theoretical metrics from structural and functional networks to assess global network topology, efficiency, and small-worldness in ALS.
• Investigate selective reorganization within motor and interhemispheric pathways by comparing resting-state and task-based functional MRI data.
• Quantify the relationship between diffusion-derived white matter connectivity and functional organization to test the disconnection model in ALS.

Strengths

• Multimodal data integration includes structural covariance, diffusion MRI tractography, and two types of functional MRI.
• Analysis employs a detailed 104-node brain parcellation scheme for network construction.
• Dataset is openly shared under a CC BY 4.0 license, facilitating reuse and collaboration.

Limitations

• The dataset is a 110.0 KB PDF file containing a research paper, not a raw or processed tabular dataset, limiting direct computational analysis.
• Sample size and specific participant counts (rows) are not provided in the available metadata.
• No raw imaging data, columnar data, or sample data files are included, only the published study results.

Provenance

Source

figshare, authored by Vijay Renga.

Collection Method

Multimodal connectomic analysis integrating cortical thickness-based structural covariance networks, diffusion MRI tractography, and resting-state and task-based functional MRI from ALS patients and matched controls.

Freshness

Last updated on 2026-03-25.