Data Sheet 3_DPP4 inhibition affects metabolism and inflammation associated pathways in hi

A transcriptomics dataset from a 2026 study investigating the role of Dipeptidyl peptidase 4 (DPP4) in Metabolic dysfunction-associated steatotic liver disease (MAFLD). The data contains gene expression changes in human induced pluripotent stem cell-derived hepatocyte-like cells under steatosis conditions and after treatment with the DPP4 inhibitor vildagliptin. The dataset was authored by Christiane Loerch and shared under a CC-BY-4.0 license.

Use Cases

• Identify differentially expressed genes in steatotic hepatocyte-like cells based on transcriptomic analyses mentioned in the description.
• Analyze the impact of DPP4 inhibition on fatty acid and purine metabolism pathways based on described gene expression regulation.
• Investigate the association between DPP4 activity and inflammation-associated pathways in MAFLD based on the study results.
• Validate in vitro stem cell models for anti-MAFLD drug discovery based on the described model system and VILDA treatment response.

Strengths

• Data is openly shared under a permissive CC-BY-4.0 license.
• Study design includes specific experimental conditions: oleic acid feeding and vildagliptin inhibition, as described.
• Analysis is based on NGS-based global transcriptomic methods, as stated in the methods section.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (751.5 KB), indicating limited scope, likely summary results rather than raw sequencing data.

Provenance

Source

figshare, author Christiane Loerch.

Collection Method

Generated from an in vitro study using human induced pluripotent stem cell-derived hepatocyte-like cells, oleic acid feeding, and vildagliptin treatment, followed by transcriptomic analysis.

Time Range

Experimental data from a study published in 2026.

Freshness

Last updated 2026-03-18 07:43:58; freshness should be verified.

Geography

Laboratory-based in vitro study; geographic origin of cells or authors is not specified.