Icaritin Effects on Allograft Rejection and Tumor Growth in Mouse Models

A research paper describing the dual role of the drug Icaritin in mouse models. The study investigates immunosuppressive and antitumor effects using heterotopic heart transplantation, single-cell RNA sequencing, and flow cytometry. The document was authored by Jinliang Duan, last updated in March 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Analyzing the molecular mechanism of Icaritin based on the described CEBPB/PIM1 axis.
• Studying Th1 cell differentiation suppression based on in vitro CD4+ T-cell culture experiments.
• Modeling drug efficacy in transplantation oncology based on the described tumor-bearing murine heart transplantation model.

Strengths

• The study includes multiple experimental methods such as scRNA-seq, flow cytometry, and molecular docking.
• The research is explicitly licensed for reuse under CC-BY-4.0.

Limitations

• The dataset is a 479.5 KB DOCX file, which is a small document rather than a structured data resource.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Experimental research involving mouse models and laboratory analysis.

Time Range

The study period is not specified.

Freshness

Last updated 2026-03-18 05:34:51; freshness should be verified.

Geography

The geographic scope is not specified.