Data Sheet 3_Dysregulated glucose metabolism in the visual cortex of human subjects with m

9.3 KB of untargeted metabolomics data from postmortem human visual cortex samples. The dataset compares control, mild cognitive impairment (MCI), and Alzheimer's disease (AD) subjects, profiling metabolites and gene expression. It was authored by Ulrik N. Mjaaseth and last updated on figshare in April 2026.

Use Cases

• Identify metabolic pathway disruptions based on untargeted metabolomics profiling
• Correlate gene expression changes with disease progression based on measured glycolytic and mitochondrial enzyme levels
• Analyze sex-stratified metabolic signatures based on the stratified analyses mentioned
• Investigate links between inflammation and metabolic decline based on TNF, IL1B, and GFAP marker data

Strengths

• Data is derived from postmortem human brain samples, a direct source for neurodegenerative disease research
• Analysis includes both metabolomic profiling and gene expression measurements for multiple pathways
• Subjects are stratified into control, MCI, and AD groups for comparative study

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data may reflect bias inherent to postmortem sample collection

Provenance

Source

figshare

Collection Method

Postmortem samples analyzed via liquid chromatography–mass spectrometry and quantitative PCR.

Freshness

Last updated 2026-04-09 05:16:18; freshness should be verified