Gut Microbiome and Mycobiome Profiles in Ulcerative Colitis Across Life Stages

73 targeted bacterial and 69 targeted fungal metagenomes from 26 pediatric and 47 adult patients with ulcerative colitis. The dataset, authored by Francesca Toto and last updated in April 2026, was analyzed to evaluate age-related variation in microbial communities while accounting for clinical heterogeneity. Results indicate fungal communities show more distinct age-related patterns than bacterial ones.

Use Cases

• Compare fungal versus bacterial community diversity patterns based on life stage (pediatric vs. adult) mentioned in the description
• Identify taxa associated with inflammation or gut health across age groups based on the enrichment analysis described
• Investigate correlations between specific microbial taxa (e.g., Faecalibacterium prausnitzii) and mucosal immune markers (e.g., lysozyme, sIgA) as outlined in the results
• Model the transition from childhood to adulthood as a critical window for host-fungal interactions based on the discussion

Strengths

• Includes 142 total metagenomic samples (73 bacterial, 69 fungal) from a defined cohort of 73 patients.
• Clinical variables such as disease activity, duration, and treatment exposure were considered in the analysis.
• Data is openly available under a CC-BY-4.0 license, facilitating reuse.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is small (261.7 KB), indicating limited scope, likely containing summary or processed results rather than raw sequencing data.
• Geographic and institutional provenance of the samples is not specified in the provided metadata.

Provenance

Source

Francesca Toto via figshare

Collection Method

Targeted metagenomic sequencing of gut bacteria and fungi from patient samples, with subsequent bioinformatic and statistical analysis.

Freshness

Last updated 2026-04-28 05:28:23; freshness should be verified.