Neurotoxicity Mechanisms of Dioctyl Terephthalate: 90 Targets and In Vivo Validation

A computational and experimental study by Hao Tang, published in 2026, investigates the neurotoxic mechanisms of the plasticizer Dioctyl Terephthalate (DOTP). The dataset likely contains results from network toxicology analysis, molecular docking, and in vivo experiments on mice. It includes 90 identified neurotoxicity-related protein targets and core nodes such as EGFR, BCL2, and CASP3.

Use Cases

• Validate network toxicology predictions based on identified protein targets like EGFR and TLR4.
• Analyze molecular docking affinities based on binding simulations with core proteins.
• Correlate in vivo behavioral and histological outcomes with predicted signaling pathways from KEGG analysis.
• Study oxidative stress and neuroinflammation markers based on results from the described in vivo assays.

Strengths

• Dataset is derived from an integrated methodology combining network prediction, molecular dynamics, and in vivo validation.
• Results are based on 90 identified neurotoxicity-related protein targets.
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 12.9 KB file size suggests a very limited scope, likely containing summary results rather than raw experimental data.

Provenance

Source

Hao Tang via figshare.

Collection Method

Data generated through computational modeling (SEA, SwissTargetPrediction, AutoDock, GROMACS) and in vivo experiments on mice.

Time Range

The study timeframe is not specified.

Freshness

Last updated 2026-04-10 05:58:45; freshness should be verified.

Geography

Geographic scope of the study is not specified.