Murine Sepsis Model Data on PD-L1 Role in Lung Injury and Mortality

Elizabeth W. Tindal's dataset contains experimental results from a study on programmed cell death receptor-ligand 1 (PD-L1) in murine shock/sepsis-induced lung injury. The data includes survival rates, lung vascular permeability measurements, and cytokine, chemokine, and angiopoietin levels from bronchoalveolar lavage fluid, lung tissue, and blood. The dataset was last updated on 2026-06-02 and is shared under a CC-BY-4.0 license.

Use Cases

• Analyze survival outcomes based on endothelial cell versus neutrophil PD-L1 deficiency.
• Model relationships between lung vascular permeability and specific biomarker concentrations.
• Compare cytokine and chemokine profiles across different tissue samples (blood, BALF, lung).

Strengths

• Dataset includes specific mortality rates over a 14-day period for different genetic models.
• Contains measurements from multiple sample types: peripheral blood, bronchoalveolar lavage fluid, and lung tissue.
• Experimental design uses controlled Cre-lox mouse models (ecPD-L1−/−, pmnPD-L1−/−) and sham procedures.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (176.5 KB), indicating a limited experimental scope.

Provenance

Source

Elizabeth W. Tindal

Collection Method

Data generated from laboratory experiments using murine models subjected to hemorrhagic shock and cecal ligation and puncture (CLP).

Freshness

Last updated 2026-06-02 04:31:27; freshness should be verified.