E. coli Urinary Tract Infection Model Data in Göttingen Minipigs

Joyce Lübbers established a novel intraurethral infection model using UPEC strain UTI89 in Göttingen minipigs, with infection sustained for 14 days. The dataset includes results from bacterial enumeration, agglutination tests, and whole genome sequencing of recovered strains. It was published on figshare under a CC-BY-4.0 license on May 18, 2026.

Use Cases

• Evaluating vaccine efficacy based on bacterial recovery data from the minipig model.
• Assessing antibiotic treatment effectiveness based on strain persistence over a 14-day infection period.
• Studying strain identity and contamination in animal models based on agglutination and whole genome sequencing results.
• Designing improved UTI animal models based on the methodological details of intraurethral challenge with Foley catheters.

Strengths

• Includes whole genome sequencing data for recovered bacterial strains.
• Documents a 14-day sustained infection model, providing a defined experimental timeframe.
• Reports specific quantitative findings, such as 75% of animals infected with the intended challenge strain.

Limitations

• Dataset scale is limited to a 44.4 KB DOCX file, suggesting a summary document rather than raw experimental data.
• Row count and column-level documentation are absent; data structure and granularity must be inferred.
• Freshness should be verified as the last update date is in the future (2026-05-18).

Provenance

Source

figshare

Collection Method

Experimental study involving intraurethral challenge of minipigs with E. coli strain UTI89, followed by urine collection, bacterial enumeration, agglutination testing, and whole genome sequencing.

Freshness

Last updated 2026-05-18 05:45:01