Gene Expression Analysis of lncRNAs in Primary Sjögren's Syndrome

A transcriptomics dataset from 126 minor salivary gland samples, including 92 from patients with primary Sjögren's syndrome and 34 controls. The data was generated by Zhongshan Li using deep stranded total transcriptome sequencing and last updated in April 2026. It includes a genome-wide competing endogenous RNA network constructed from 3,035 lncRNAs and 10,838 coding genes.

Use Cases

• Identify differentially expressed lncRNAs and coding genes based on the genome-wide sequencing data.
• Analyze regulatory networks and ceRNA interactions based on the constructed network of shared miRNA binding sites.
• Validate candidate lncRNA functions in disease pathogenesis based on the three experimentally validated lncRNAs (BISPR, LINC00926, HCP5).
• Explore correlations between lncRNA expression and clinical features of pSS as suggested by the study results.

Strengths

• Includes data from 126 patient and control samples, providing a basis for comparative analysis.
• Contains a constructed genome-wide ceRNA network with 3,035 lncRNAs and 10,838 coding genes.
• Three key lncRNA regulatory roles were validated by in vitro experiments, adding experimental support.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The primary data file is a 1.5 MB PDF, which may require extraction and processing to access underlying data.

Provenance

Source

figshare

Collection Method

Deep stranded total transcriptome sequencing performed on minor salivary gland samples.

Time Range

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Freshness

Last updated 2026-04-15 05:33:17; freshness should be verified.

Geography

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