Genomic Determinants of Antifungal Activity in Streptomyces Strain STM-2

Presenting genomic analysis results for Streptomyces melanosporofaciens STM-2, a strain isolated from Chiayi County, Taiwan. The analysis identified 52 biosynthetic gene clusters (BGCs) and specific genes for antifungal enzymes. It was generated by Muhammed Opoku Gyamfi using genome mining and comparative genomics.

Use Cases

• Identify and analyze the 52 predicted biosynthetic gene clusters (BGCs) for potential novel antimicrobial compounds.
• Model the 3D structure of unique gene products associated with antifungal activity using provided AlphaFold2 pLDDT scores.
• Compare the accessory genome of strain STM-2 against other strains to study genes linked to specialized antifungal activity.
• Examine the predicted repertoire of tailoring enzymes (P450s, glycosyltransferases, halogenase candidates) for biotechnological applications.

Strengths

• Identifies a specific count of 52 biosynthetic gene clusters (BGCs) through genome mining.
• Provides high-confidence structural evidence via AlphaFold2 models with very high pLDDT scores.
• Focuses on a novel Streptomyces melanosporofaciens strain with confirmed antifungal activity from a specific location (Chiayi County, Taiwan).

Limitations

• The dataset is very small at 10.9 KB, indicating limited scope and likely summary-level data rather than raw genomic sequences.
• Rows and columns are unknown, preventing assessment of data volume and granularity.
• Findings are based on a single, unique strain (STM-2), limiting generalizability to other organisms.

Provenance

Source

figshare, authored by Muhammed Opoku Gyamfi.

Collection Method

Generated through genome mining, comparative genomics, and evolutionary analysis of a whole-genome sequence.

Freshness

Last updated March 20, 2026.

Geography

Chiayi County, Taiwan (source of the isolated STM-2 strain).