Gene Therapy Effects on Liver Gene Expression in GH-Resistant Mice

RNA-seq data from male and female mouse livers, comparing wild-type, GHR-deficient (Laron), and gene therapy-treated groups. The dataset, authored by Joshua K. Tay and last updated in May 2026, includes results showing 448 genes with significant expression changes following therapy. It highlights the upregulation of IGF signaling genes and enrichment of sex-biased genes.

Use Cases

• Analyze differential gene expression patterns based on comparisons between wild-type, knockout, and treatment groups.
• Investigate sex-biased gene regulation in the liver based on the enrichment for sex-biased genes mentioned in the description.
• Study the effects of a constitutively active liver-specific promoter on gene expression based on the reported upregulation of proto-oncogenes.
• Evaluate the efficacy of AAV-mediated gene replacement therapy for Laron syndrome based on the measured changes in IGF1 and IGFALS expression.

Strengths

• Includes RNA-seq data from four distinct experimental groups (wild-type, knockout, treatment, and vector control).
• Reports specific quantitative results, such as a 16-fold induction of IGF1 and IGFALS genes.
• License is CC-BY-4.0, allowing for open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (1.2 MB), suggesting it may contain summary results rather than raw sequence data.

Provenance

Source

figshare

Collection Method

RNA sequencing performed on mouse liver samples from controlled laboratory experiments.

Freshness

Last updated 2026-05-28 04:56:28; freshness should be verified.