Hypoxia Inducible Factor 1 Alpha and Autophagy in Oral Lichen Planus

A 58.1 KB PDF research article by Xie Li, published on figshare in 2026, investigates the role of HIF-1α in autophagy dysfunction in oral lichen planus. The study uses a simulated inflammatory cell model and C. elegans experiments to show HIF-1α inhibits lysosomal genes and impairs autophagy. Findings suggest targeted inhibition of HIF-1α could restore autophagy function as a potential therapeutic strategy.

Use Cases

• Analyze the relationship between HIF-1α expression and autophagy markers based on mRNA and protein level comparisons.
• Study the impact of lysosomal pathway disruption on cell activity based on mechanistic findings in the simulated OLP model.
• Investigate genetic knockdown effects on organism lifespan based on C. elegans experiments with hif-1, bec-1, and lgg-1 genes.

Strengths

• Data is openly licensed under CC-BY-4.0.
• The description provides a detailed mechanistic study linking HIF-1α to autophagy dysfunction.
• The dataset was last updated on 2026-04-14.

Limitations

• The dataset is a 58.1 KB PDF, which is a very small research article, not a primary data file.
• Column-level documentation and sample data are unavailable; data must be extracted manually from the text.
• Row count and specific data formats for underlying experimental results are unknown.

Provenance

Source

figshare, author Xie Li.

Collection Method

Likely contains experimental results from cell model studies and C. elegans lifespan assays.

Freshness

Last updated 2026-04-14 04:21:24.