Shared APC Neoantigen Data for Cancer Vaccine Proof-of-Concept

Over 80% of colorectal cancer cases are linked to mutations in the APC gene. Alfred J. Simmons authored this research data, which details the identification of shared neoantigen epitopes from the APC gene's mutational cluster region and the development of a self-amplifying RNA vaccine candidate. The dataset, last updated on 2026-06-04, provides proof-of-concept for a vaccine approach against APC-associated colorectal cancer.

Use Cases

• Identifying shared neoantigen epitopes based on the mutational cluster region of the APC gene.
• Designing cancer vaccine constructs based on mutated APC sequences inserted into a wild-type APC backbone.
• Evaluating in vitro T-cell activation and restimulation based on neoantigen peptide fragments.
• Assessing in vivo immune response based on serum IgG titers from vaccinated mouse models.

Strengths

• Focuses on a high-impact target, as over 80% of colorectal cancer cases involve APC gene mutations.
• Provides in vitro and in vivo validation data, including T-cell activation and significant IgG titers in mice.
• Released under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Dataset scope is limited to a 249.5 KB PDF file, suggesting a small-scale, focused study rather than a large data repository.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect the specific experimental bias inherent to the described proof-of-concept study.

Provenance

Source

figshare

Collection Method

Bioinformatics analysis and experimental validation (in vitro T-cell assays, in vivo mouse model immunization).

Freshness

Last updated 2026-06-04 05:19:34; freshness should be verified.