Common Genes in Diabetic Nephropathy and Retinopathy from Transcriptome Data

A 2026 study by Juan He identified 206 common genes between diabetic nephropathy (DN) and diabetic retinopathy (DR) from transcriptome data GSE185011. The analysis screened 526 DN-related and 1,059 DR-related differentially expressed genes, ultimately identifying 6 diagnostic genes for DN and 4 for DR. The research includes immune cell infiltration analysis and constructed TF-mRNA-miRNA regulatory networks to explore molecular mechanisms.

Use Cases

• Identifying diagnostic biomarkers for diabetic nephropathy based on the 6 screened genes (METTL27, NMNAT2, TTC25, GAS6, ATP4A, ZNF223).
• Investigating shared pathogenic mechanisms between diabetic nephropathy and retinopathy based on the 206 common genes.
• Analyzing immune cell infiltration differences, such as central memory CD4 T cells in DN and activated B cells in DR.
• Studying gene regulatory networks based on the constructed 493 TF-6mRNA-183miRNA network for DN and 111 TF-4mRNA-33miRNA network for DR.

Strengths

• Identifies 206 common genes from 526 DN-related and 1,059 DR-related differentially expressed genes.
• Screens specific diagnostic gene sets: 6 for diabetic nephropathy and 4 for diabetic retinopathy.
• Includes analysis of immune cell infiltration and constructed TF-mRNA-miRNA regulatory networks.

Limitations

• Dataset size is 116.4 KB, indicating a very limited scope of data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Transcriptome data analysis from dataset GSE185011 using differential expression screening and enrichment analyses.

Freshness

Last updated 2026-04-28 05:24:43; freshness should be verified.