Gut Microbiota and Metabolite Associations with Oral Cancer via Mendelian Randomization

A 2026 analysis by Junfeng Guo uses bidirectional two-sample Mendelian randomization to explore causal links between gut microbiota, circulating metabolites, and oral cancer. The study integrates data from genome-wide association studies for 471 gut microbial taxa, 233 circulating metabolites, and oral cancer, with findings validated using clinical multi-omics samples. It identifies specific microbial taxa and metabolites with positive or negative causal relationships to oral cancer, including mediated pathways.

Use Cases

• Identify potential causal gut microbial taxa for oral cancer risk based on reported odds ratios and p-values.
• Investigate the mediating role of specific circulating metabolites like citrate and omega-3 fatty acids in the gut-oral cancer relationship.
• Validate Mendelian randomization findings using independent clinical multi-omics profiling data mentioned in the description.
• Explore genetic instrument data from genome-wide association studies for 471 microbial taxa and 233 metabolites.

Strengths

• Analysis is based on data from genome-wide association studies for 471 gut microbial taxa and 233 circulating metabolites.
• Employs multiple Mendelian randomization methods (IVW-MR, GSMR) and reports checks for pleiotropy and heterogeneity.
• Findings are supported by clinical validation using multi-omics profiling.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 2.5 MB DOCX document, which may not be a standard format for structured data analysis.

Provenance

Source

Junfeng Guo via figshare.

Collection Method

Bidirectional two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies, supplemented by clinical sample validation.

Freshness

Last updated 2026-05-21 05:45:50; freshness should be verified.