Ankylosing Spondylitis Biomarkers: Integrated Stress Response Genes and Drug Predictions

Transcriptomic and Mendelian randomization analysis identifies RORA, FBXO31, and MSRB3 as causal biomarkers for ankylosing spondylitis. The 147.0 KB dataset includes results from functional enrichment, immune infiltration analysis, and drug predictions for indirubin and pentoxifylline. Shuai Wang published the data on figshare under a CC-BY-4.0 license, with a last update in March 2026.

Use Cases

• Validate candidate biomarkers (RORA, FBXO31, MSRB3) for ankylosing spondylitis based on transcriptomic and Mendelian randomization results.
• Investigate immune cell infiltration correlations, particularly with Th1 cells and keratinocytes, as described in the analysis.
• Explore potential drug repurposing for ankylosing spondylitis based on predicted agents like indirubin and pentoxifylline.
• Study the role of olfactory transduction pathways in autoimmune disease pathogenesis as indicated by functional enrichment results.

Strengths

• Dataset is validated by RT–qPCR on clinically collected blood samples, as mentioned in the methods.
• Analysis employs multiple techniques: transcriptomic profiling, Mendelian randomization, and drug prediction.
• Published under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The 147.0 KB file size suggests a limited scope, likely containing summary results rather than raw sequencing data.
• Geographic and demographic coverage of the patient samples is not specified in the provided metadata.

Provenance

Source

figshare, author Shuai Wang.

Collection Method

Transcriptomic profiling of peripheral blood from AS patients, followed by Mendelian randomization and functional analyses.

Freshness

Last updated 2026-03-26 06:26:59.