Plasma Exosomal Proteomics Data for Thyroid Disorders and Papillary Carcinoma

Yawei Zhang's dataset contains proteomic profiles of plasma-derived exosomes from patients with papillary thyroid carcinoma (PTC), PTC with Hashimoto’s thyroiditis (HT), HT alone, and healthy controls. The data includes 45 differentially expressed proteins identified via label-free quantitative proteomics and subsequent validation. The dataset was last updated on 2026-05-25.

Use Cases

• Identify candidate protein biomarkers for papillary thyroid carcinoma based on exosomal protein expression.
• Investigate the molecular link between Hashimoto’s thyroiditis and thyroid cancer progression based on pathway enrichment results.
• Validate proteomic discoveries using parallel reaction monitoring (PRM) data for proteins like SVEP1 and IGKV3-7.

Strengths

• Includes data from four distinct patient cohorts (PTC, PTC-W, HT, HCs) for comparative analysis.
• Validation phase confirmed specific protein biomarkers (SVEP1 and IGKV3-7) with statistical significance.
• Functional annotation provides insights into extracellular matrix and immune response pathways.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in size (164.4 KB), indicating a limited scope of data.

Provenance

Source

Yawei Zhang via figshare

Collection Method

Exosomes were isolated from plasma samples, and proteins were analyzed using label-free quantitative proteomics.

Freshness

Last updated 2026-05-25 04:45:00; freshness should be verified.